A　pyridinium-based　immobilized　ionic　liquid　type　multifunctional　hybrid　silica　monolith　was　prepared　by　the　in　situ　polymerization　of　3-chloropropyl-silica　matrix　and　4,4′-dipyridyl　for　hydrophilic　interaction　CEC.　The　obtained　hybrid　monolith　possessed　of　high　stable　skeletal　microstructures　with　obviously　hydrophilic　retention　mechanism　under　ACN　content　＞50%　in　the　mobile　phase.　Strong　and　stable　anodic　EOF　could　be　observed　under　a　broad　pH　range　from　pH　3.0　to　9.0.　Due　to　the　immobilized　dipyridyl　groups　bonded　to　the　silica　matrix　surface,　the　resulting　hydrophilic　hybrid　monolith　possessed　multiple　separation　interactions　including　hydrogen　bond,　π-π,　and　anion　exchange.　Excellent　separations　of　various　polar　analytes　including　electroneutral　phenols,　charged　acid　nucleotides,　and　basic　analytes　were　successfully　achieved.　The　highest　column　efficiencies　up　to　120000,　164000,　and　106000　plates/m　were　obtained　for　nucleotides,　nucleic　acid　bases,　and　nucleosides　and　nicotines,　respectively.　These　results　demonstrated　that　the　dipyridyl-immobilized　ionic　liquid　functionalized　hybrid　monolith　possessed　highly　mechanical　stability　and　good　chromatographic　performance　for　hydrophilic　interaction　electrochromatography.　©　2013　WILEY-VCH　Verlag　GmbH　&　Co.　KGaA,　Weinheim.