To　optimum　the　chelation　technology　of　whey　protein　hydrolysate　with　calcium,　the　response　surface　method　was　used　to　investigate　optimized　technological　conditions.　The　result　showed　that　the　optimum　process　parameters　for　the　whey　protein　hydrolysate-calcium　chelation　were　whey　protein　peptide　and　CaCl2　ratio　of　24:　1　(w/w),　whey　protein　hydrolysate　concentration　3.5%,　pH　7.5,　reaction　time　20　min,　reaction　temperature　30　°C.　Finally,　the　optimum　level　was　established　and　whey　protein　hydrolysate-calcium　chelate　was　obtained,　which　can　provide　basic　theories　for　the　following　function　and　activity　evaluation　of　this　potential　calcium　supplement.　©　(2013)　Trans　Tech　Publications,　Switzerland.