A novel strategy for targeting photodynamic therapy. Molecular combo of photodynamic agent zinc(II) phthalocyanine and small molecule target-based anticancer drug erlotinib - Details

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Abstract：

In　this　study,　two　phthalocyanine-erlotinib　conjugates　linked　by　an　oligoethylene　glycol　chain　have　been　synthesised　and　fully　characterised.　Having　erlotinib　as　the　targeting　moiety,　the　two　conjugates　exhibited　high　specific　affinity　to　HepG2　cancer　cells　and　tumour　tissues,　therefore　leading　to　high　photodynamic　activity.　©　The　Royal　Society　of　Chemistry　2013.

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[ 1 ] [Zhang, F.-L.]College of Chemistry and Chemical Engineering, Fuzhou University, Fuzhou 350108, China
[ 2 ] [Huang, Q.]College of Chemistry and Chemical Engineering, Fuzhou University, Fuzhou 350108, China
[ 3 ] [Zheng, K.]College of Chemistry and Chemical Engineering, Fuzhou University, Fuzhou 350108, China
[ 4 ] [Li, J.]College of Chemistry and Chemical Engineering, Fuzhou University, Fuzhou 350108, China
[ 5 ] [Liu, J.-Y.]College of Chemistry and Chemical Engineering, Fuzhou University, Fuzhou 350108, China
[ 6 ] [Xue, J.-P.]College of Chemistry and Chemical Engineering, Fuzhou University, Fuzhou 350108, China

Reprint 's Address：

[Liu, J.-Y.]College of Chemistry and Chemical Engineering, Fuzhou University, Fuzhou 350108, China

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liujianyong82@163.com

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Chemical Communications

ISSN： 1359-7345

Year： 2013

Issue： 83

Volume： 49

Page： 9570-9572

6 . 7 1 8

JCR@2013

4 . 3 0 0

JCR@2023

JCR Journal Grade：1

CAS Journal Grade：2

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SCOPUS Cited Count： 76

ESI Highly Cited Papers on the List： 0 Unfold All

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30 Days PV： 1

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