In vitro antiproliferative effect of a water-soluble Laminaria japonica polysaccharide on human melanoma cell line A375 - Details

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Abstract：

A　water-soluble　polysaccharide　WPS-2-1,　purified　from　Laminaria　japonica,　has　been　found　to　have　antitumor　activity.　In　this　study,　WPS-2-1　exhibited　high　anti-proliferative　activity　on　A375　cells　in　a　dosedependent　manner.　Further　investigation　indicated　that　WPS-2-1　induced　A375　cells　apoptosis.　Moreover,　WPS-2-1-induced　apoptosis　was　associated　with　the　alteration　in　expressions　of　Bcl-2　family　proteins.　Mitochonadrial　apoptotic　pathway　was　involved　in　WPS-2-1-induced　apoptosis,　which　included　the　loss　of　mitochondrial　membrane　and　activation　of　caspase-3/9.　The　results　in　this　study　suggested　that　WPS-2-1　could　effectively　inhibit　proliferation　of　A375　cells　in　vitro　and　induce　apoptosis　via　mitochondrial　apoptotic　pathway.　It　might　serve　as　a　potential　antitumor　agent.　©　2013　Elsevier　Ltd.

Keyword：

A375 cells; Antitumor activity; Apoptosis; Bcl-2 family proteins; Laminaria japonica polysaccharide

Community：

[ 1 ] [Peng, Z.]Institute of Biomedical and Pharmaceutical Technology, Fuzhou University, Fuzhou, China
[ 2 ] [Peng, Z.]College of Chemistry and Chemical Engineering, Fuzhou University, Fuzhou, China
[ 3 ] [Liu, M.]Institute of Biomedical and Pharmaceutical Technology, Fuzhou University, Fuzhou, China
[ 4 ] [Liu, M.]College of Chemistry and Chemical Engineering, Fuzhou University, Fuzhou, China
[ 5 ] [Fang, Z.]Institute of Biomedical and Pharmaceutical Technology, Fuzhou University, Fuzhou, China
[ 6 ] [Chen, L.]Institute of Biomedical and Pharmaceutical Technology, Fuzhou University, Fuzhou, China
[ 7 ] [Wu, J.]Institute of Biomedical and Pharmaceutical Technology, Fuzhou University, Fuzhou, China
[ 8 ] [Zhang, Q.]Institute of Biomedical and Pharmaceutical Technology, Fuzhou University, Fuzhou, China
[ 9 ] [Zhang, Q.]Institute of Biomedical Engineering, Chinese Academy of Medical Science, Peking Union Medical College, Tianjin, China

Reprint 's Address：

[Zhang, Q.]Institute of Biomedical and Pharmaceutical Technology, Fuzhou University, Fuzhou, China

Email：

zhangqiq@126.com

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Food and Chemical Toxicology

ISSN： 0278-6915

Year： 2013

Volume： 58

Page： 56-60

2 . 6 1

JCR@2013

3 . 9 0 0

JCR@2023

JCR Journal Grade：1

CAS Journal Grade：2

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ESI Highly Cited Papers on the List： 0 Unfold All

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30 Days PV： 0

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