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author:

Ou, L. (Ou, L..) [1] | Chen, Y. (Chen, Y..) [2] | Su, Y. (Su, Y..) [3] | Huang, Y. (Huang, Y..) [4] | Chen, R. (Chen, R..) [5] | Lei, J. (Lei, J..) [6]

Indexed by:

Scopus

Abstract:

This work aims to explore the application of silver nanoparticle-based surface-enhanced Raman scattering (SERS) for nasopharyngeal carcinoma cell line CNE2's DNA analysis after X-ray radiation. The cells are separated into control group and radiated groups with different dose of 6, 10, 15 and 20 Gy. The results show that after radiation (6, 10, 15 and 20 Gy), the DNA of radiated CNE2 have changed after 72 h of cell incubation. Principal components analysis is employed for significant differences and the DNA extracted after 72 h of incubation show significant divisions from control group. Moreover, a classifier based on support vector machines shows high classification accuracy between DNA extracted after 72 h of incubation and control group. In conclusion, this study first reveals SERS characteristics of CNE2's DNA under different dose of X-ray radiation, and the final results may do favor to make known the mechanism of X-ray radiation interacting with tumor. Copyright © 2013 John Wiley & Sons, Ltd.

Keyword:

DNA; nasopharyngeal carcinoma; silver nanoparticle; surface-enhanced Raman scattering (SERS); X-ray radiation

Community:

  • [ 1 ] [Ou, L.]Key Laboratory of Optoelectronic Science and Technology for Medicine, Ministry of Education, Fujian Normal University, Fuzhou, China
  • [ 2 ] [Chen, Y.]Zhicheng College, Fuzhou University, Fuzhou, China
  • [ 3 ] [Su, Y.]Laboratory of Radiobiology, Fujian Provincial Tumor Hospital, Fuzhou, China
  • [ 4 ] [Huang, Y.]Key Laboratory of Instrumentation Science and Dynamic Measurement, North University of China, Taiyuan, China
  • [ 5 ] [Chen, R.]Key Laboratory of Optoelectronic Science and Technology for Medicine, Ministry of Education, Fujian Normal University, Fuzhou, China
  • [ 6 ] [Lei, J.]Key Laboratory of Optoelectronic Science and Technology for Medicine, Ministry of Education, Fujian Normal University, Fuzhou, China

Reprint 's Address:

  • [Chen, Y.]Zhicheng College, Fuzhou University, Fuzhou, China

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Source :

Journal of Raman Spectroscopy

ISSN: 0377-0486

Year: 2013

Issue: 5

Volume: 44

Page: 680-685

2 . 5 1 9

JCR@2013

2 . 4 0 0

JCR@2023

JCR Journal Grade:2

CAS Journal Grade:2

Cited Count:

WoS CC Cited Count:

SCOPUS Cited Count:

ESI Highly Cited Papers on the List: 0 Unfold All

WanFang Cited Count:

Chinese Cited Count:

30 Days PV: 0

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