Aculeatusquinones a-d, novel metabolites from the marine-derived fungus aspergillus aculeatus - Details

author：

Indexed by：

Scopus

Abstract：

Four　new　aculeatusquinones　A-D　(1-4)　and　five　known　compounds,　(5aS,6S,7S)-3,7-dihydroxy-6-methoxy-1,4,6,9-tetramethyl-6,7-dihydro-5aHdibenzo[　b,e][1,4]dioxepine-8,11-dione　(5),　3,8-dihydroxy-1,4,6,9-tetramethyldibenzo[　b,e][1,4]dioxepin-11-one　(6),　4-O-demethylbarbatic　acid　(7),　atraric　acid　(8),　and　2,5-dimethyl-1,3-benzenediol　(9),　were　isolated　from　the　marine-derived　fungus　Aspergillus　aculeatus.　The　structures　of　the　new　compounds　were　elucidated　by　spectroscopic　methods,　including　one-　and　two-dimensional　NMR　and　high-resolution　mass　spectrometric　analyses.　Two　new　compounds　(2　and　4)　showed　cytotoxic　effects　on　the　HL-60,　K562,　and　A-549　cell　lines,　with　IC50　values　ranging　from　5.4　μM　to　76.1　μM.　©　2013　The　Japan　Institute　of　Heterocyclic　Chemistry.

Keyword：

Community：

[ 1 ] [Chen, L.]Institute of Biomedical and Pharmaceutical Technology, College of Chemistry and Chemical Engineering, Fuzhou University, Fuzhou, 350002, China
[ 2 ] [Zhang, W.-W.]Institute of Biomedical and Pharmaceutical Technology, College of Chemistry and Chemical Engineering, Fuzhou University, Fuzhou, 350002, China
[ 3 ] [Zheng, Q.-H.]Surgical Laboratory, Fujian Provincial Cancer Hospital, Fuzhou, 350014, China
[ 4 ] [Liu, Q.-Y.]Surgical Laboratory, Fujian Provincial Cancer Hospital, Fuzhou, 350014, China
[ 5 ] [Zhong, P.]Institute of Biomedical and Pharmaceutical Technology, College of Chemistry and Chemical Engineering, Fuzhou University, Fuzhou, 350002, China
[ 6 ] [Hu, X.]Institute of Biomedical and Pharmaceutical Technology, College of Chemistry and Chemical Engineering, Fuzhou University, Fuzhou, 350002, China
[ 7 ] [Fang, Z.X.]Institute of Biomedical and Pharmaceutical Technology, College of Chemistry and Chemical Engineering, Fuzhou University, Fuzhou, 350002, China
[ 8 ] [Zhang, Q.Q.]Institute of Biomedical and Pharmaceutical Technology, College of Chemistry and Chemical Engineering, Fuzhou University, Fuzhou, 350002, China
[ 9 ] [Zhang, Q.Q.]Institute of Biomedical Engineering, Chinese Academy of Medical Science, Peking Union Medical College, Tianjin, 300192, China

Reprint 's Address：

[Chen, L.]Institute of Biomedical and Pharmaceutical Technology, College of Chemistry and Chemical Engineering, Fuzhou University, Fuzhou, 350002, China

Email：

ibptcl@fzu.edu.cn

Show more details

Related Keywords：

Source ：

Heterocycles

ISSN： 0385-5414

Year： 2013

Issue： 4

Volume： 87

Page： 861-868

0 . 9 0 8

JCR@2013

0 . 8 0 0

JCR@2023

JCR Journal Grade：3

CAS Journal Grade：4

Cited Count：

WoS CC Cited Count：

SCOPUS Cited Count：

ESI Highly Cited Papers on the List： 0 Unfold All

WanFang Cited Count：

Chinese Cited Count：

30 Days PV： 0

Affiliated Colleges：

Get Fulltext

DOI Library Discovery Baidu Scholar Search SCOPUS

Type
Departments

All Years Choose Year From to