Isobaric　vapor-liquid　equilibria　(VLE)　were　measured　for　the　binary　system　acetone.　+.　acetone　oxime　methyl　ether　(AOME)　at　101.3.　kPa.　The　activity　coefficients　were　correlated　satisfactorily　with　NRTL　and　Wilson　models.　The　thermodynamic　consistency　of　the　obtained　VLE　data　was　checked　by　Herington　method　and　passed　the　test.　The　results　show　that　the　correlated　data　of　NRTL　and　Wilson　models　are　both　in　keep　with　the　experimental　data,　and　the　UNIFAC　parameters　of　the　new　group　(C.　N)　were　determined　using　the　obtained　VLE　data.　The　azeotrope　behavior　is　not　happen　for　the　binary　system　of　acetone.　+.　AOME,　which　can　provide　the　basis　data　to　design　the　separation　process,　and　promote　the　development　of　new　technology　to　produce　O-methylhydroxyamine　hydrochloride　effectively　and　economically.　©　2013　Elsevier　B.V.