Heat-integrated　pressure　swing　distillation　for　separation　of　methyl　acetate　and　methanol　was　investigated　based　on　the　pressure-sensitivity　of　azeotropic　composition.　The　separation　process　was　simulated　by　Aspen　Plus　software　using　the　thermodynamic　model　NRTL　with　binary　parameters　between　two　components　obtained　by　experimental　data　of　vapor　liquid　equilibrium　(VLE).　The　influences　of　number　of　theoretical　plates,　feeding　location　and　reflux　ratio　on　the　separation　efficiency　and　energy　consumption　of　high-pressure　distillation　and　atmospheric　distillation　columns　were　analyzed.　The　results　show　that　they　are　efficiently　separated　by　heat-integrated　pressure　swing　distillation,　and　the　optimal　conditions　are　as　follows:　for　high-pressure　column,　the　pressure　is　909　kPa,　number　of　theoretical　plates　32,　feeding　location　at　the　21th　plate,　and　reflux　ratio　4.2,　the　purity　of　methyl　acetate　reaches　99.8%　at　the　bottom　of　tower;　for　atmospheric　pressure　column,　the　pressure　is　101　kPa,　number　of　theoretical　plates　30,　feeding　location　at　the　20th　plate,　and　reflux　ratio　4.6,　the　purity　of　methanol　reaches　99.0%　at　the　bottom　of　tower.　The　heat-integrated　pressure　swing　distillation　can　save　energy　by　45.8%　compared　with　conventional　one,　and　the　former　is　also　more　attractive　than　the　extractive　distillation　using　water　as　an　entrainer　for　separation　of　azeotropic　system.