Bi-directional　pseudo-dynamic　test　and　nonlinear　seismic　response　analysis　were　conducted　on　a　1:2　scaled　two-story　brick　masonry　building　model　with　precast　floor　slabs　under　different　seismic　intensities　to　investigate　its　seismic　behavior　including　the　failure　mechanism,　deformation,　hysteretic　characteristics　and　energy　dissipation,　etc.　Some　important　conclusions　can　be　drawn　from　the　testing　and　analysis　and　are　listed　as　follows.　The　existence　of　constructional　columns　and　ring　beams　in　masonry　building　with　precast　floor　slabs　can　effectively　resist　horizontal　earthquake　loadings　and　result　in　good　ductility.　The　earthquake　damage　and　failure　concentrate　at　the　lower　story　of　the　two-story　masonry　building.　Even　if　the　brick　walls　are　severely　cracked,　the　whole　structure　may　not　collapse　suddenly.　The　seismic　performance　of　masonry　structure　in　the　horizontal　X　and　Y　directions　are　different.　Under　the　bi-directional　earthquake　loading,　degradation　of　stiffness　and　strength　in　one　direction　may　aggravate　to　the　degradation　of　stiffness　and　strength　in　the　other　direction,　resulting　in　the　overall　degradation　of　seismic　performance　of　masonry　building.　The　hysteresis　loops　start　from　the　bow　shape　and　become　reversed　S-shape　at　the　failure　stage.　The　constructed　non-linear　space　finite　element　(FE)　model　of　brick　masonry　building　can　predict　the　elasto-plastic　seismic　performance　of　masonry　structures　with　precast　floor　slabs.　The　calculation　results　from　FE　simulation　are　basically　consistent　with　the　results　from　testing.　The　designed　two-story　brick　masonry　building　model　can　meet　siesmic　requirements　of　design　codes.