Composition and cytotoxicity of a novel polysaccharide from brown alga (Laminaria japonica) - Details

author：

Peng, Z. (Peng, Z..) ^[1] | Liu, M. (Liu, M..) ^[2] | Fang, Z. (Fang, Z..) ^[3] | Wu, J. (Wu, J..) ^[4] | Zhang, Q. (Zhang, Q..) ^[5]

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Abstract：

A　novel　polysaccharide　WPS-2-1,　with　an　average　molecular　weight　of　80　kDa,　was　purified　from　aqueous　extracts　of　Laminaria　japonica.　Monosaccharides　analysis　revealed　that　WPS-2-1　was　composed　of　mannose,　rhamnose　and　fucose　with　a　molar　ratio　of　1.0:2.3:1.2.　Analysis　by　periodate　oxidation-Smith　degradation　indicated　that　WPS-2-1　had　a　backbone　of　array　by　(1　→　4)-glycosidic　linkages.　Cytotoxicity　assay　showed　that　WPS-2-1　presented　significantly　higher　antitumor　activities　against　A375　and　BGC823　cells　with　a　dose-dependent　manner,　and　exhibited　lower　cytotoxicity　to　vascular　smooth　muscle　cells.　The　results　suggested　that　WPS-2-1　should　be　explored　as　a　potential　antitumor　agent　with　low　toxicity.　©　2012　Elsevier　Ltd.　All　rights　reserved.

Keyword：

Antitumor activity; Laminaria japonica polysaccharide; Low cytotoxicity; Structure characterization

Community：

[ 1 ] [Peng, Z.]Institute of Biomedical and Pharmaceutical Technology, Fuzhou University, Fuzhou, China
[ 2 ] [Peng, Z.]College of Chemistry and Chemical Engineering, Fuzhou University, Fuzhou, China
[ 3 ] [Liu, M.]Institute of Biomedical and Pharmaceutical Technology, Fuzhou University, Fuzhou, China
[ 4 ] [Liu, M.]College of Chemistry and Chemical Engineering, Fuzhou University, Fuzhou, China
[ 5 ] [Fang, Z.]Institute of Biomedical and Pharmaceutical Technology, Fuzhou University, Fuzhou, China
[ 6 ] [Wu, J.]Institute of Biomedical and Pharmaceutical Technology, Fuzhou University, Fuzhou, China
[ 7 ] [Zhang, Q.]Institute of Biomedical and Pharmaceutical Technology, Fuzhou University, Fuzhou, China
[ 8 ] [Zhang, Q.]Institute of Biomedical Engineering, Chinese Academy of Medical Science, Peking Union Medical College, Tianjin, China

Reprint 's Address：

[Zhang, Q.]Institute of Biomedical and Pharmaceutical Technology, Fuzhou University, Fuzhou, China

Email：

zhangqiq@126.com

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Source ：

Carbohydrate Polymers

ISSN： 0144-8617

Year： 2012

Issue： 4

Volume： 89

Page： 1022-1026

3 . 4 7 9

JCR@2012

1 0 . 7 0 0

JCR@2023

JCR Journal Grade：1

CAS Journal Grade：1

Cited Count：

WoS CC Cited Count：

SCOPUS Cited Count： 56

ESI Highly Cited Papers on the List： 0 Unfold All

WanFang Cited Count：

Chinese Cited Count：

30 Days PV： 1

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