MIMO-OFDM　is　a　promising　technique　for　the　broadband　wireless　communication　system.　In　this　paper,　we　propose　a　novel　scheme　that　integrates　multiple-description　coding　(MDC),　error-resilient　video　coding,　and　unequal　error　protection　strategy　with　hybrid　space-time　coding　structure　for　robust　video　transmission　over　MIMO-OFDM　system.　The　proposed　MDC　coder　generates　multiple　bitstreams　of　equal　importance　which　are　very　suitable　for　multiple-antennas　system.　Furthermore,　according　to　the　contribution　to　the　reconstructed　video　quality,　we　apply　unequal　error　protection　strategy　using　BLAST　and　STBC　space-time　codes　for　each　video　bitstream.　Experimental　results　have　demonstrated　that　the　proposed　scheme　can　be　an　excellent　alternative　to　achieve　desired　tradeoff　between　the　reconstructed　video　quality　and　the　transmission　efficiency.