Site-specific hydrolytic cleavage of oxidized insulin B chain with Zn(II) ion studied by electrospray ionization mass spectrometry and MS/MS mass spectrometry - Details

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author：

Jiang, J. (Jiang, J..) ^[1] | Mei, Y.-H. (Mei, Y.-H..) ^[2] | Wang, W.-J. (Wang, W.-J..) ^[3] | Wu, Q.-J. (Wu, Q.-J..) ^[4] | Zhu, L.-G. (Zhu, L.-G..) ^[5]

Indexed by：

Scopus PKU CSCD

Abstract：

The　bonding　interaction　and　hydrolytic　cleavage　of　oxidized　insulin　B　chain　with　ZnCl2　in　molar　ratios　of　1:1　1:2　and　1:3　at　pH　value　of　2.5　and　40　°C　were　investigated　by　electrospray　ionization　mass　spectrometry　and　tandem　mass　spectrometry.　The　results　show　that　the　binding　sites　of　Zn　2+　with　oxidized　insulin　B　chain　are　Arg22　and　imidazole　groups　of　His5,　His10,　which　leads　to　the　selective　cleavages　of　the　peptide　bonds　at　Asn3-Gln4,　His5-Leu6,　Gly8-Ser9　and　Glu21-Arg22　of　oxidized　insulin　B　chain.

Keyword：

Hydrolytic cleavage; Mass spectrometry; Oxidized insulin B; ZnCl2

Community：

[ 1 ] [Jiang, J.]College of Chemistry and Chemical Engineering, Fuzhou University, Fuzhou 350002, China
[ 2 ] [Jiang, J.]College of Life Science, Fujian Agriculture and Forestry University, Fuzhou 350002, China
[ 3 ] [Mei, Y.-H.]State Key Laboratory of Coordination Chemistry, Nanjing University, Nanjing 210093, China
[ 4 ] [Wang, W.-J.]College of Chemistry and Chemical Engineering, Fuzhou University, Fuzhou 350002, China
[ 5 ] [Wu, Q.-J.]College of Life Science, Fujian Agriculture and Forestry University, Fuzhou 350002, China
[ 6 ] [Zhu, L.-G.]State Key Laboratory of Coordination Chemistry, Nanjing University, Nanjing 210093, China

Reprint 's Address：

[Jiang, J.]College of Chemistry and Chemical Engineering, Fuzhou University, Fuzhou 350002, China

Email：

fuzhoujiang_1969@yahoo.com.cn

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Source ：

Chinese Journal of Inorganic Chemistry

ISSN： 1001-4861

Year： 2007

Issue： 6

Volume： 23

Page： 948-956

0 . 5 6 9

JCR@2007

0 . 8 0 0

JCR@2023

JCR Journal Grade：4

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WoS CC Cited Count：

SCOPUS Cited Count：

ESI Highly Cited Papers on the List： 0 Unfold All

WanFang Cited Count：

Chinese Cited Count：

30 Days PV： 1

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