Novel silicon phthalocyanines axially modified by morpholine: Synthesis, complexation with serum protein and in vitro photodynamic activity - Details

author：

Zhu, Y.-J. (Zhu, Y.-J..) ^[1] | Huang, J.-D. (Huang, J.-D..) ^[2] | Jiang, X.-J. (Jiang, X.-J..) ^[3] | Sun, J.-C. (Sun, J.-C..) ^[4]

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Abstract：

Two　novel　morpholine-containing　silicon　(IV)　phthalocyanines,　namely　bis　(2-morpholine)　ethoxy　phthalocyaninatosilicon　(2)　and　bis　(2-(N-methyl-morpholine))　ethoxy　phthalocyaninatosilicon　diiodide　(3),　have　been　prepared.　The　complexations　of　these　two　compounds　with　three　serum　proteins　including　the　bovine　serum　albumin,　human　serum　albumin,　and　transferrin　have　also　been　investigated.　The　non-aggregated　compound　3　exhibits　a　high　photodynamic　activity　towards　B16　melanoma　tumour　cells　with　an　IC50　value　of　0.30　μM.　©　2006　Elsevier　B.V.　All　rights　reserved.

Keyword：

Photodynamic therapy; Photosensitizer; Serum protein; Silicon phthalocyanine

Community：

[ 1 ] [Zhu, Y.-J.]College of Chemistry and Chemical Engineering, Fuzhou University, Fuzhou, 350002, China
[ 2 ] [Huang, J.-D.]College of Chemistry and Chemical Engineering, Fuzhou University, Fuzhou, 350002, China
[ 3 ] [Huang, J.-D.]State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou, 350002, China
[ 4 ] [Jiang, X.-J.]College of Chemistry and Chemical Engineering, Fuzhou University, Fuzhou, 350002, China
[ 5 ] [Sun, J.-C.]Department of Pharmacology, Fujian Medical University, Fuzhou, Fujian 350004, China

Reprint 's Address：

[Huang, J.-D.]College of Chemistry and Chemical Engineering, Fuzhou University, Fuzhou, 350002, China

Email：

jdhuang@fzu.edu.cn

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Source ：

Inorganic Chemistry Communications

ISSN： 1387-7003

Year： 2006

Issue： 5

Volume： 9

Page： 473-477

1 . 7 8 7

JCR@2006

4 . 4 0 0

JCR@2023

JCR Journal Grade：2

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