Abstract:
线粒体自噬(mitophagy)是指特异清除受损或多余线粒体的过程,是一种重要的线粒体质量控制机制。线粒体自噬功能障碍或线粒体自噬过度激活都会破坏线粒体稳态,影响机体健康甚至导致死亡。主要讨论了在酵母和哺乳动物细胞中发现的正向调控线粒体自噬的机制:在酵母中,线粒体自噬是由自噬相关蛋白32(autophagy-related protein 32,Atg32)介导的;而哺乳动物体内线粒体自噬的调控途径主要有3种:PTEN诱导激酶1(PTEN-induced kinase 1,PINK1)/E3泛素连接酶Parkin途径、类NIP3蛋白X(NIP3-like protein X,Nix)途径、携带...
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生物技术进展
Year: 2019
Issue: 05
Volume: 9
Page: 467-475
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ESI Highly Cited Papers on the List: 0 Unfold All
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30 Days PV: 3
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