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author:

刘格 (刘格.) [1] | Peng Xu (Peng Xu.) [2] | Mingdong Huang (Mingdong Huang.) [3] (Scholars:黄明东) | Jinyu Li (Jinyu Li.) [4] (Scholars:李金宇)

Abstract:

Urokinase-type plasminogen activator(uPA) is a potential therapeutic target for cancerXREFX.1 Very recently, we reported a cyclic peptide-based inhibitor(IG-2, CPAYSRYIGC) of murine u PA with high potency and specificity(Ki=6.8 nM).2-3 However, the potency of IG-2 against human uPA(huPA) was much we...

Keyword:

cancer therapy molecular dynamic simulation peptide inhibitor uPA

Community:

  • [ 1 ] National & Local Joint Biomedical Engineering Research Center on Photodynamic Technologies,College of Chemistry, Fuzhou University
  • [ 2 ] Institute of Molecular and Cell Biology,A*STAR
  • [ 3 ] 福州大学

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Year: 2019

Language: Chinese

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ESI Highly Cited Papers on the List: 0 Unfold All

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Chinese Cited Count:

30 Days PV: 2

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