At　present,　high-sensitivity,　high-penetrationdepth,　and　accurate　tissue　resolution　clinical　imaging　effect　are　required,　while　computer　transverse　scanning,　microwave　imaging,　and　fluorescence　imaging　(FL)　cannot　meet　the　requirements　of　clinical　imaging,　but　the　magnetic　resonance　imaging　(MRI)　can　meet　the　requirements　of　clinical　dissecting　details.　The　effect　of　MRI　imaging　is　closely　related　to　the　contrast　agent　(CA).　As　an　important　type　of　CA,　Fe3O4　and　its　analogues　have　been　widely　concerned　because　of　their　low　toxicity　and　relatively　low　price.　In　this　review,　we　summarize　the　development　and　improvement　of　CAs　based　on　Fe3O4　and　its　analogues　from　T-2　imaging　mode　and　development　limitation　in　the　initial　single　modulus　imaging　mode,　to　T-1　imaging　mode　overcoming　the　limitations　of　T-2　imaging　and　the　limitations　of　its　own　in　application,　to　the　later　development　of　dual　modulus　imaging　form,　and　to　the　current　multi-modulus　imaging　form.　Simultaneously,　we　demonstrate　the　research　progress,　preparation　methods,　and　future　trends　based　on　Fe3O4　and　its　analogues　CAs　for　MRI,　the　current　application　status　is　preliminarily　summarized,　and　the　future　development　trend　is　prospected.