A　pilot-scale　vacuum　membrane　distillation　(VMD)　demonstration　plant　for　decontamination　of　radioactive　wastewater　with　8.0　m(3)/d　water　production　was　developed.　The　design　scheme,　main　components　and　functions　of　VMD　pilot　plant　were　detailed.　Effects　of　operational　parameters　on　permeate　flux,　gain　output　ratio　(GOR)　and　decontamination　factor　(DF)　of　simulated　radioactive　wastewater　were　analyzed.　As　feed　temperature　increased　from　70　degrees　C　to　90　degrees　C,　permeate　flux　grew　exponentially　from　1.59　kg/(m(2).h)　to　6.82　kg/(m(2).h).　High　DF　10(4.)(85)　of　Cs+　and　high　concentration　factor　(CF)　110.3　of　simulated　radioactive　wastewater　were　reached　with　stable　permeate　flux　in　pilot-plant-scale.　DF　of　Cs+　and　GOR　were　relatively　stable　under　various　operation　conditions.　The　outlet　temperature　of　membrane　modules　increased　with　the　growth　of　flow　rate,　bringing　about　9　degrees　C　temperature　difference　between　2　m(3)/h　and　14　m(3)/h　at　the　same　inlet　temperature　of　70　degrees　C.　The　significant　heat　loss　in　radial　direction　as　temperature　polarization　and　in　axial　direction　as　the　heat　pinch　effect　in　hollow　fiber　membrane　modules　are　the　main　issues　for　large-scale　MD　plant.　This　study　demonstrates　a　remarkable　potential　of　VMD　for　decontamination　of　radioactive　wastewater　and　provides　an　integrated　design　of　VMD　pilot-scale　plant.