The　increased　emission　of　CO2　has　negative　impacts　on　the　environment.　Among　the　strategies,　photocatalytic　reduction　is　promising　to　convert　the　CO2　into　chemicals.　In　this　report,　CoOx　nanoparticles　were　loaded　in　the　channels　of　MIL-101(Cr),　a　kind　of　metal-organic　frameworks　(MOF),　to　construct　a　novel　CoOx/MIL-101(Cr)　system　to　facilitate　CO2　photoreduction.　Under　the　optimal　conditions,　the　CoOx/MIL-101(Cr)　showed　a　significantly　enhanced　performance　for　photocatalytic　CO2　reduction　compared　with　bare　CoOx　and　MIL-101(Cr).　Our　findings　provide　a　pathway　for　a　rational　design　of　efficient　MOF　systems　for　the　photocatalytic　reduction　of　CO2.