Photodynamic　therapy　(PDT)　as　a　clinical　cancer　treatment　method　has　been　used　to　treat　carcinomas　in　different　organs,　and　G-quadruplex-based　DNA　nanocompartments　serving　as　the　carriers　of　cationic　porphyrin　photosensitizers,　especially　combined　with　cell-targeting　aptamers,　is　considered　to　offer　new　opportunities　for　future　cancer　treatment.　However,　the　structural　features　of　G-quadruplex/aptamer　complexes　suitable　for　the　capsulation　of　photosensitizers　and　target　cell　recognition　is　unexplored　so　far.　In　this　study,　unimolecular　(UM),　bimolecular　(BM)　and　tetramolecular　(TM)　G-quadruplex　structures　were　used　as　the　drug　loading　compartments　and　grafted　onto　tumor　cell-targeting　aptamer　Sgc8,　constructing　several　targeting　drug　delivery　vehicles　(T-GMVs).　Besides　the　binding　affinity　of　resulting　DNA　architectures　for　target　cells　and　cell　recognition　specificity　were　explored　in　a　comparative　fashion,　the　drug　loading　capability　and　cancer　therapy　efficacy　were　evaluated　using　TMPyP4　as　the　model　porphyrin-based　drug.　The　experimental　results　show　that　only　TM　G-quadruplex　structure　is　suitable　to　combine　with　Sgc8　for　the　development　of　drug　delivery　vehicle　and　the　as-prepared　T-GMV-TMPyP4　complexes　display　the　desirable　cancer　therapy　efficacy,　holding　the　potential　application　in　the　future　cancer　therapy.　More　importantly,　T-GMV-TMPyP4　is　expected　to　lay　the　scientific　groundwork　for　the　successful　development　of　G-quadruplex-based　photosensitizer　drug　delivery　carriers　for　the　targeted　cancer　therapy.