Radix　Pseudostellariae　protein　(RPP)　with　satisfactory　antioxidant　activity　and　self-assembled　ability　was　extracted　from　dried　Radix　Pseudostellariae.　In　this　study,　RPP-curcumin　nanocomplex　(RPP-Cur)　was　fabricated,　and　its　improvement　on　the　stability,　cellular　uptake　and　antioxidant　activity　of　curcumin　was　investigated.　RPP-Cur　with　homogeneously　spherical　structure　exhibited　good　stability,　which　could　maintain　the　morphology　against　simulated　gastrointestinal　digestion　and　up　to　300　mM　ionic　concentration.　After　RPP　nanoparticles　encapsulation,　the　retention　of　curcumin　increased　1.45　times　under　UV　irradiation　for　6　h.　Besides,　RPP-Cur　exhibited　additive　reducing　power　of　curcumin　and　RPP.　The　transport　efficiency　of　hydrophobic　curcumin　across　Caco-2　cells　monolayer　was　greatly　improved　by　RPP　nanoparticle　by　3.7　folds.　RPP-Cur　was　able　to　be　internalized　by　Caco-2　cells　dose-dependently　via　macropinocytosis　and　clathrin-mediated　endocytosis.　The　cellular　uptake　efficiency　of　embedded　curcumin　in　RPP　nanoparticles　by　Caco-2　cells　was　significantly　higher　than　that　of　free　curcumin,　which　might　contribute　to　the　enhanced　intracellular　antioxidant　activity　of　RPP-Cur.　These　findings　suggest　that　the　proteins　from　Radix　Pseudostellariae　have　potential　to　be　developed　into　novel　delivery　system　with　intrinsic　antioxidant　activity　for　the　hydrophobic　active　molecules　in　healthy　food　field.