Indexed by:
Abstract:
To date, hydrogen (H-2) therapy has received widespread attention. However, X-ray triggered sustainable H-2-producing materials with controlled release for cancer treatment have not been reported. Herein, an X-ray triggered sustainable in situ H-2 producing platform, Au NR-TiO2@ZnS:Cu,Co-A(Au-TiO2@ZnS), composed of Au-amorphous TiO2 nano-dumbbell-shaped heterostructure coated with long afterglow particles, was developed for cancer synergistic H-2-radiotherapy. The mechanism of H-2 production was verified by theoretical calculations and in vitro experiments. Changes in the apoptosis pathway caused by the synergistic effect of H-2 and radiotherapy were reported. Guided by its excellent photoacoustic imaging capabilities, mice with orthotopic liver cancer achieved excellent therapeutic effects and low inflammatory side effects, suggesting that Au-TiO2@ZnS has promising application potential for cancer treatment and prognosis.
Keyword:
Reprint 's Address:
Email:
Version:
Source :
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
ISSN: 1433-7851
Year: 2021
Issue: 23
Volume: 60
Page: 12868-12875
1 6 . 8 2 3
JCR@2021
1 6 . 1 0 0
JCR@2023
ESI Discipline: CHEMISTRY;
ESI HC Threshold:117
JCR Journal Grade:1
CAS Journal Grade:2
Cited Count:
WoS CC Cited Count: 0
SCOPUS Cited Count: 38
ESI Highly Cited Papers on the List: 0 Unfold All
WanFang Cited Count:
Chinese Cited Count:
30 Days PV: 1
Affiliated Colleges: