Objective:　To　synthesize　and　determine　the　antifungal　activity　of　AgBr-nanoparticles　(NP)　@CTMAB　(cetyltrimethyl-ammonium　bromide)　against　Candida　albicans　(C.　albicans)　for　use　in　the　field　of　denture　cleaning.　Methods:　The　morphology　and　structure　of　AgBr-NP@CTMAB　were　characterized　by　IR,　UV-Vis,　XRD　and　SEM.　The　antifungal　potential　of　AgBr-NP@CTMAB　against　C.　albicans　was　determined　by　colony　formation　assay　and　growth　curve　analysis.　PMMA　containing　AgBr-NP@CTMAB　was　prepared,　and　the　long-term　antifungal　efficacy　was　analyzed.　The　effect　against　C.　albicans　biofilm　was　analyzed　by　SEM　and　OD600,　and　the　color　changes　of　the　specimens　were　observed　by　stereomicroscopy　after　1　week　of　incubation.　Cytotoxicity　to　human　oral　gingival　fibroblasts　and　oral　mucosal　epithelial　cells　was　detected　by　Cell　Counting　Kit-8　(CCK-8)　in　vitro.　Results:　The　compound　showed　a　good　crystalline　phase,　the　presence　of　AgBr　nanoparticles　and　the　hybridization　of　CTMAB+　with　AgBr-NPs.　AgBr-NP@CTMAB　showed　significant　antifungal　activity　against　C.　albicans　at　concentrations　of　10　mu　g/mL　and　20　mu　g/mL.　PMMA　specimens　containing　AgBr-NP@CTMAB　showed　no　long-term　antifungal　effect　against　C.　albicans　biofilm.　The　clearance　rate　of　C.　albicans　attached　to　PMMA　was　44.73%　after　soaking　in　10　mu　g/mL　AgBr-NP@CTMAB　solution　for　30　min　and　91.35%　for　8　h.　There　was　no　significant　residual　cytotoxicity　or　visual　color　change　after　soaking.　Significance:　AgBr-NP@CTMAB　showed　promising　potential　treatment　for　denture　cleaners.