The　coronavirus　disease　2019　(COVID-19)　pandemic　has　caused　both　physical　and　psychological　changes　in　the　general　public.　The　current　study　aimed　to　examine　the　relationship　between　well-being　and　coping　strategies　in　response　to　the　pandemic.　Furthermore,　we　aimed　to　investigate　the　mediational　role　of　benefit　finding.　A　total　of　521　participants　aged　18-65　years　were　recruited　from　29　regions　of　mainland　China.　Situation-specific　coping　strategies,　including　support　seeking,　personal　hygiene　practice　and　social　distancing,　were　measured　at　Time　1.　Benefit　finding　and　well-being　were　assessed　1　month　later.　A　multilevel　mediation　model　was　conducted　with　region　included　in　level　2　as　cluster　ID.　Support　seeking　and　personal　hygiene　practice　were　positive　predictors　of　benefit　finding,　which　further　mediated　their　relationships　with　well-being,　while　social　distancing　negatively　predicted　well-being.　These　results　highlight　the　relationships　of　support　seeking,　personal　hygiene　practice　and　benefit　finding　with　well-being　during　the　COVID-19　pandemic.　Our　findings　indicate　that　besides　adopting　adaptive　coping　strategies　to　prevent　infection　by　COVID-19,　individuals　should　be　encouraged　to　recognize　benefits　associated　with　the　COVID-19　outbreak.