The　emergence　of　antibiotic-resistant　bacteria　poses　a　serious　challenge　to　medical　practice　worldwide.　A　small　peptide　with　sequence　RWRWRW　was　previously　identified　as　a　core　antimicrobial　peptide　with　limited　antimicrobial　spectrum　to　bacteria,　especially　Gram-positive　bacteria.　By　conjugating　this　peptide　and　its　analogs　with　lipophilic　phthalocyanine　(Pc),　we　identified　a　new　antibiotic　peptide　[PcG(3)K(5)(RW)(3)].　The　peptide　demonstrates　increased　antimicrobial　effect　to　both　Gram-positive　Staphylococcus　aureus　and　Gram-negative　Escherichia　coli.　In　addition,　Pc　also　provides　added　and　potent　antimicrobial　effect　upon　red　light　illumination.　The　inhibitory　efficacy　of　PcG(3)K(5)(RW)(3)　was　increased　by　similar　to　140-fold　to　nanomolar　range　upon　illumination.　Moreover,　PcG(3)K(5)(RW)(3)　was　safe　for　mammalian　cell　and　promoted　wound　healing　in　the　mouse　infection　model.　Our　work　provides　a　new　direction　to　optimize　antimicrobial　peptides　to　enhance　antimicrobial　efficacy.