The　paper　presents　and　discusses　the　dynamic　response　of　a　curved　cable-stayed　bridge　in　Venice　(Italy).　Two　distinct　experimental　campaigns　in　2010　and　2011　led　to　identifying　the　bridge　dynamic　characteristics　in　operational　conditions.　The　dynamic　identification　included　the　characterization　of　both　the　deck　and　cables　response.　The　authors　developed　a　highly　refined　finite　element　(FE)　model　of　the　bridge,　mirroring　up　to　twelve　experimental　modes.　An　updating　procedure　drove　the　estimate　of　the　optimum　parameters　associated　with　the　lowest　discrepancy　with　the　experimental　modal　parameters.　The　calibrated　model　was　the　base　of　a　parametric　analysis　on　the　effects　of　the　deck　curvature,　cables　arrangement　and　tower　cross-section　inertia　on　the　bridge　dynamics.　Specifically,　the　authors　developed　fourteen　FE　models　of　the　bridge　distinguished　by　the　lack　and　different　arrangement　of　the　stay　cables,　the　increasing　value　of　the　deck　curvature　and　the　tower　cross-section　inertia.　The　analysis　intends　to　quantify　the　impact　of　the　design　choices　of　cable-stayed　bridges　on　the　modal　parameters.