Objectives　The　current　tooth　bleaching　materials　are　associated　with　adverse　effect.　Photodynamic　method　based　on　a　novel　photosensitizer　alone,　without　combining　with　peroxides,　is　evaluated　for　tooth　bleaching　application.　Materials　and　methods　Teeth　samples　were　randomly　divided　into　3　groups　with　different　treatment　schemes,　including　negative　control　group　(group　A,　physiological　saline),　experimental　group　(group　B,　ZnPc(Lys)(5)),　and　the　positive　control　group　(group　C,　hydrogen　peroxide).　Tooth　color,　surface　microhardness,　and　roughness　were　determined　at　baseline,　right　after　the　first　and　second　phase　of　bleaching,　as　well　as　1　week　and　1　month　post-bleaching.　Four　samples　in　each　group　was　randomly　selected　to　evaluate　the　changes　in　surface　morphology　using　the　scanning　electron　microscope.　Results　The　color　change　values　(Delta　E)　in　group　B　(7.10　+/-　1.03)　and　C　(12.22　+/-　2.35)　were　significantly　higher　than　that　in　group　A　(0.93　+/-　0.30,　P　＜　0.05).　Additionally,　surface　microhardness　and　roughness　were　significantly　affected　in　group　C,　but　not　in　the　group　A　and　B.　Furthermore,　the　scanning　electron　microscope　images　showed　no　adverse　effect　of　enamel　in　the　group　A　and　B　while　the　group　C　demonstrated　corrosive　changes.　Conclusions　ZnPc(Lys)(5)　had　a　satisfactory　bleaching　effect　and　is　promising　to　be　a　new　type　of　tooth　bleaching　agent.