Brassinosteroids　(Brs)　are　a　class　of　plant　polyhydroxysteroids　and　play　pivotal　roles　in　plant　growth　and　development.　Furthermore,　Brs　are　involved　in　the　responses　of　plants　to　various　heavy　metal　stresses.　However,　the　role　of　Brs　in　the　translocation　and　uptake　of　arsenic　(As)　and　cadmium　(Cd)　in　rice　(Oryza　sativa　L.)　remains　largely　unknown.　The　present　study　was　performed　to　examine　the　impacts　of　24-epibrassinolide　(Br24:　10(-1)0　and　10(-8)　M),　28-homobrassinolide　(Br28:　10(-10)　and　10(-8)　M),　FeSO4　addition　(1　g　kg(-1)　Fe)　and　their　interactions　on　the　accumulation　of　As　and　Cd　by　rice　in　pot　trials.　The　results　showed　that　the　Fe　content　in　iron　plaque　was　increased　by　Fe　addition　but　not　by　Br24/Br28.　The　interactions　of　Br24/Br28　and　Fe　enhanced　the　Fe　contents　in　roots　and　stems.　Br24/Br28　or　Fe　addition　decreased　the　translocation　and　accumulation　of　As　and　Cd　in　rice　grains.　The　interactions　of　Br24/Br28　or　Fe　further　reduced　the　contents　of　As　and　Cd　in　rice　grains.　The　As　contents　in　grain　were　reduced　by　60%　under　Fe　addition,　18%-63%　under　Br24,　56%-73%　under　Fe+Br24,　and　66%-72%　under　Fe+Br28.　The　grain　Cd　contents　were　reduced　by　65%　under　Fe　addition,　33%-61%　under　Br24,　56%-67%　under　Fe+Br24,　and　43%-66%　under　Fe+Br28.　These　results　suggest　that　the　application　of　Fe,　Br24/Br28　or　their　combination　is　effective　in　reducing　the　contents　of　As　and　Cd　in　rice　grains,　which　has　strong　implications　for　agricultural　production　and　food　security.　(C)　2021　Elsevier　B.V.　All　rights　reserved.