Frequent　leaks　of　hazardous　chemicals　have　a　huge　impact　on　human　lives,　property　and　the　ecological　environment.　Therefore,　the　three-dimensional　functional　porous　materials　with　high　absorption　efficiency　and　special　wettability　for　the　disposal　of　hazardous　chemical　spills　is　an　urgent　demand.　In　this　work,　a　series　of　spherical　beads　consisting　of　partially　reduced　graphene　oxide　(prGO)　and　MXene　(Ti3C2Tx)　nanosheets　were　constructed　by　hydrogen　bond　induced　self-assembly　along　with　freeze-drying　and　thermal　treatment.　The　lightweight　and　amphipathic　prGO/MXene　spherical　beads　(prGMSBDs)　had　millimeter-level　size,　spherical　morphology　and　highly　porous　internal　structure,　which　were　especially　suitable　for　eliminating　hazardous　chemicals.　Because　of　their　excellent　thermal　stability　and　fire　retardance,　the　prGMSBDs　could　be　used　to　absorb　flammable　organic　liquids,　reducing　the　fire　risk　of　the　flammable　hazardous　chemical　spills.　Indeed,　the　prGMSBDs　exhibited　outstanding　absorption　performances　for　various　hazardous　chemicals,　including　organic　solvents　and　water-based　concentrated　acid　and　alkali.　Moreover,　the　prGMSBDs　showed　relatively　stable　absorption　performance　after　five　absorption-drying　cycles.　Due　to　meeting　the　requirements　of　both　amphipathic　characteristic　and　flame　retardancy,　the　prGMSBDs　reported　in　this　work　may　offer　a　promising　strategy　for　rapidly　cleaning　up　various　hazardous　chemicals　and　open　a　feasible　route　to　protecting　the　combustible　hazardous　chemical　spills　from　fire.　©　2021　Elsevier　B.V.