Optical　security　labels　play　a　significant　role　in　protecting　both　our　wealth　and　health.　However,　simultaneously　meeting　the　requirements　including　low-cost　fabrication,　easy　detection,　and　high-level　security　is　still　challenging　for　security　labels.　Here,　we　design　an　unclonable　anti-counterfeiting　system　with　triple-level　security　by　using　the　inkjet　printing　technique,　which　can　be　authenticated　by　naked　eyes,　a　portable　microscope,　and　a　fluorescence　microscope.　These　labels　are　achieved　by　printing　microscale　quantum　dot　(QD)　ink　droplets　on　premodified　substrates　with　random-distributed　glass　microspheres.　Due　to　the　unique　capillary　action　induced　by　the　glass　microspheres,　QDs　in　the　ink　droplets　are　deposited　around　the　microspheres,　forming　microscale　multicircular　patterns.　Multiple　pinning　of　QDs　at　the　three-phase　contact　lines　appears　during　the　evaporation　of　the　droplet,　resulting　in　the　formation　of　a　nanoscale　labyrinthine　pattern　around　the　microspheres.　The　nanoscale　labyrinth　pattern　and　the　microscale　multicircular　microsphere　array,　together　with　the　printed　macroscopic　image,　constitute　a　triple-level　progressive　anti-counterfeiting　system.　Moreover,　the　system　is　compatible　with　an　artificial　intelligence-based　identification　strategy　that　allows　rapid　identification　and　verification　of　the　unclonable　security　labels.　©　2021　American　Chemical　Society.