Entangled　Porous　Titanium　Alloy　Metal　Rubber　(EPTA-MR)　was　used　as　a　nucleus　pulposus　material　in　the　design　of　non-fusion　intervertebral　disc　prosthesis　for　the　first　time.　A　novel　artificial　lumbar　intervertebral　disc　prosthesis　was　designed　by　reconstructing　the　lumbar　model　with　reverse　engineering　technology,　and　the　biomechanical　behavior　of　the　prosthesis　was　simulated　under　varied　working　conditions.　The　nucleus　pulposus　size　was　determined　by　the　actual　size　of　human　prosthesis.　EPTA-MR　samples　with　different　densities　were　prepared　by　medical　titanium　alloy　wire　experimental　studies　were　conducted　on　static　stiffness,　damping　energy　consumption,　and　fatigue　life.　The　results　indicated　that　the　static　stiffness　of　EPTA-MR　could　reach　approximately　1500　N·mm−1,　and　its　loss　factor　remained　higher　than　0.2,　and　the　variation　range　was　relatively　small,　with　excellent　vibration　damping　capacity　and　bearing　capacity.　Among　them,　the　overall　performance　of　EPTA-MR　with　a　density　of　2.5　g·cm−3　was　closer　to　that　of　the　physiologic　intervertebral　disc.　A　macro　experiment　of　five　million　fatigue　vibration　tests　combined　with　microstructure　observation　exhibited　a　wear　rate　of　only　0.9396　g·MC−1,　with　no　noticeable　change　in　the　internal　micro-morphology.　Therefore,　the　EPTA-MR　has　a　broad　application　prospect　as　the　nucleus　pulposus　material　of　artificial　intervertebral　disc　prosthesis.　©　2021,　Jilin　University.