A　large　number　of　toxic　fumes　evolved　from　polymeric　materials　are　a　great　threat　to　human　evacuation.　The　aim　of　this　work　is　to　dramatically　reduce　the　generation　of　smoke　and　toxic　gaseous　products　upon　polymers　burning.　A　highly　efficient　titanium　carbide/nano-copper　(Ti3C2Tx/Nano-Cu)　hybrid　smoke　suppressant　was　synthesized　by　interficial　adhesion　and　then　incorporated　into　thermoplastic　polyurethane　(TPU)　to　fabricate　TPU　nanocomposites.　The　Ti3C2Tx/Nano-Cu　hybrid　was　homogeneously　dispersed　in　the　TPU　matrix　and　showed　a　strong　interfacial　interaction　with　the　TPU　host.　Introducing　the　Ti3C2Tx/Nano-Cu　hybrid　into　TPU　led　to　enhanced　high-temperature　stability.　Furthermore,　the　smoke　production　rate,　CO　production　rate　and　total　CO　yield　of　the　TPU　nanocomposite　containing　2　wt%　Ti3C2Tx/Nano-Cu　hybrid　decreased　by　66.7%,　51.8%　and　52.9%,　respectively,　compared　with　those　of　pure　TPU.　The　reduced　fire　hazards　of　the　TPU　were　due　to　the　physical　barrier,　the　catalytic　charring　and　the　chemical　conversion　of　Ti3C2Tx/Nano-Cu　hybrid.　©　2021　Elsevier　Ltd