Osteoarthritis　disease　can　easily　lead　to　articular　cartilage　degeneration　and　subchondral　bone　damage,　so　the　demand　for　suitable　articular　substitutes　is　gradually　increasing.　In　order　to　simulate　the　complex　environment　of　different　layers　in　natural　joint,　we　fabricate　the　continuous　one-phase　gradient　scaffold.　In　the　study,　CS　(chitosan)　was　modified　with　SH　(sodium　hyaluronate)　and　GO　(graphene　oxide)　to　form　the　whole　scaffold.　nHAP　(Nano-hydroxyapatite)　was　in　situ　generated　with　gradient　distribution　in　the　scaffold.　Continuous　interface　can　better　imitate　the　combination　style　of　cartilage　and　subchondral　bone　at　joint.　The　diverseness　of　scaffold＇s　different　layer　in　water　absorption/retention　rate　and　mechanical　property　is　similar　to　the　difference　of　articular　cartilage　and　subchondral　bone.　Meanwhile,　the　cell　experiments　demonstrated　that　the　bionic　scaffold　can　well　promote　the　proliferation　of　bone　marrow　mesenchymal　stem　cell.　Articular　defect　model　further　confirmed　that　the　scaffold　can　better　induce　articular　regeneration.　Herein,　the　prepared　scaffold　might　be　an　excellent　candidate　for　endogenous　articular　repair.　©　2021　Elsevier　B.V.