To　fully　disclose　potential　configurations　of　parallel　mechanisms　(PMs)　that　are　performance-comparable　to　the　commercially　successful　Exechon,　a　family　of　one　translational　two　rotational　(1T2R)　over-constrained　Exechon　inspired　PMs　is　synthesized　through　the　screw　theory.　The　synthesized　PMs　are　further　comparatively　analyzed　in　terms　of　inverse　kinematics,　singularity　occurrence　and　reachable　workspace　based　on　a　unified　kinematic　model.　The　kinematic　analyses　indicate　that　the　inherited　overconstraints　benefit　for　eliminating　the　constraint　singularity　of　all　synthesized　Exechon　inspired　PMs　and　the　workspace　distribution　of　an　Exechon　inspired　PM　is　closely　related　to　its　topological　arrangement.　Based　on　the　kinematic　evaluations,　a　preferred　configuration　of　2UPR-1RPS　PM　(‘R’:　revolute　joint,　‘U’:　universal　joint,　‘S’:　spherical　joint,　‘P’:　prismatic　actuated　joint)　is　selected　as　a　candidate　for　1T2R　spindle　head.　A　laboratory　prototype　is　fabricated　and　experimentally　tested　to　verify　the　feasibility　of　the　type　synthesis　and　the　correctness　of　the　kinematic　analyses.　By　integrating　the　selected　PM　with　a　2-degree　of　freedom　sliding　gantry,　a　full　scale　prototype　of　a　novel　hybrid　kinematic　machine　tool　is　developed　to　perform　5-axis　machining　tasks.　The　well　match　between　the　machined　workpiece　and　its　designed　shape　fully　proves　the　engineering　potential　of　the　synthesized　PMs　that　are　expected　to　be　employed　as　the　functional　module　to　construct　5-axis　serial-parallel　hybrid　machining　devices.　©　2021　Elsevier　Ltd