The　ability　to　combine　the　color-tunability　capability　of　natural　organisms　with　a　memory　function　in　a　single　device　is　highly　desired　and　holds　promise　for　potential　applications　such　as　intelligent　artificial　skin　and　human-machine　interfaces.　In　this　work,　we　propose　a　universal　strategy　to　realize　color-tunable　skin　with　the　compound　function　of　memory　by　ingeniously　integrating　a　memristor　interface　into　a　flexible　quantum-dot　light-emitting　device.　The　devices　developed　using　this　strategy　have　multiple　responses　to　electrical　and　light　stimulations　and　can　easily　change　their　color　over　a　wide　range　from　red　to　green.　Moreover,　these　color-tunable　devices　can　mimic　the　unique　function　of　＇once　bitten,　twice　shy＇　to　enhance　self-protection,　and　their　color　tunability　is　consistent　with　the　memory-forgetting　curve　proposed　by　psychologists.　©　2021