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author:

Bai, Shumeng (Bai, Shumeng.) [1] | Zhang, Mengya (Zhang, Mengya.) [2] | Huang, Xiaowei (Huang, Xiaowei.) [3] | Zhang, Xueliang (Zhang, Xueliang.) [4] | Lu, Chunhua (Lu, Chunhua.) [5] | Song, Jibin (Song, Jibin.) [6] | Yang, Huanghao (Yang, Huanghao.) [7]

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EI

Abstract:

Despite advances in the development of osteo-regenerative biomaterials, current products are vulnerable to stress-induced formation of cracks, resulting in the loss of functionality and a limited lifespan. In the present study, a strategy based on host-guest assembly was developed to fabricate a silk fibroin-based inorganic-organic hybrid hydrogel (termed SF@HG@HA) in which silk fibroin was used as a polymer template to tether host (β-cyclodextrin) and guest (cholesterol) monomers, respectively. Due to dynamic host-guest interactions, the prepared hydrogel could repair itself spontaneously when damaged, without the assistance of any external stimuli, mimicking the self-healing characteristics of native bone tissue. Furthermore, the efficient energy dissipation mechanism provided by the host-guest crosslinking strategy endowed the hydrogel with robust mechanical properties to bear substantial mechanical loading. SF@HG@HA was shown to support cell proliferation and osteogenic differentiation in vitro and accelerate bone regeneration in critical-size rat femoral defects in vivo. Together, the silk fibroin-based self-healing hydrogel with robust mechanical properties shows potential applications in the reconstruction of bone defects, which may provide new directions for the design of functional biomaterials for tissue regeneration. © 2020

Keyword:

Biomechanics Bone Cell proliferation Crosslinking Defects Energy dissipation Hydrogels Mechanical properties Self-healing materials Tissue Tissue regeneration

Community:

  • [ 1 ] [Bai, Shumeng]College of Biological Science and Engineering, Fuzhou University, Fuzhou; 350108, China
  • [ 2 ] [Zhang, Mengya]College of Biological Science and Engineering, Fuzhou University, Fuzhou; 350108, China
  • [ 3 ] [Huang, Xiaowei]MOE Key Laboratory for Analytical Science of Food Safety and Biology, Fujian Provincial Key Laboratory of Analysis and Detection Technology for Food Safety, State Key Laboratory of Photocatalysis on Energy and Environment, College of Chemistry, Fuzhou University, Fuzhou; 350108, China
  • [ 4 ] [Huang, Xiaowei]Industrial Research Institute of Nonwovens and Technical Textiles, College of Textiles and Clothing, Qingdao University, Qingdao; 266071, China
  • [ 5 ] [Zhang, Xueliang]College of Biological Science and Engineering, Fuzhou University, Fuzhou; 350108, China
  • [ 6 ] [Lu, Chunhua]MOE Key Laboratory for Analytical Science of Food Safety and Biology, Fujian Provincial Key Laboratory of Analysis and Detection Technology for Food Safety, State Key Laboratory of Photocatalysis on Energy and Environment, College of Chemistry, Fuzhou University, Fuzhou; 350108, China
  • [ 7 ] [Song, Jibin]MOE Key Laboratory for Analytical Science of Food Safety and Biology, Fujian Provincial Key Laboratory of Analysis and Detection Technology for Food Safety, State Key Laboratory of Photocatalysis on Energy and Environment, College of Chemistry, Fuzhou University, Fuzhou; 350108, China
  • [ 8 ] [Yang, Huanghao]College of Biological Science and Engineering, Fuzhou University, Fuzhou; 350108, China
  • [ 9 ] [Yang, Huanghao]MOE Key Laboratory for Analytical Science of Food Safety and Biology, Fujian Provincial Key Laboratory of Analysis and Detection Technology for Food Safety, State Key Laboratory of Photocatalysis on Energy and Environment, College of Chemistry, Fuzhou University, Fuzhou; 350108, China

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Source :

Chemical Engineering Journal

ISSN: 1385-8947

Year: 2021

Volume: 413

1 6 . 7 4 4

JCR@2021

1 3 . 4 0 0

JCR@2023

ESI HC Threshold:105

JCR Journal Grade:1

CAS Journal Grade:1

Cited Count:

WoS CC Cited Count: 0

SCOPUS Cited Count: 23

ESI Highly Cited Papers on the List: 0 Unfold All

WanFang Cited Count:

Chinese Cited Count:

30 Days PV: 1

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