Poly[(9,9-dioctylfluorenyl-2,7-diyl)-alt(4,4′-(N-(4-butylphenyl))]　(TFB),　one　of　the　most　popular　and　widely　used　hole-transport　layer　(HTL)　materials,　has　been　successfully　applied　in　high　performance　spin-coated　quantum　dots-based　light-emitting　diodes　(QLEDs)　due　to　its　suitable　energy　level　and　high　mobility.　However,　there　are　still　many　challenging　issues　in　inkjet-printed　QLED　devices　when　using　TFB　as　HTL.　TFB　normally　suffers　from　the　interlayer　mixing　and　erosion,　and　low　surface　energy　against　the　good　film　formation.　Here,　a　novel　environment-friendly　binary　solvent　system　was　established　for　formulating　quantum　dot　(QD)　inks,　which　is　based　on　mixing　halogen-free　alkane　solvents　of　decalin　and　n-tridecane.　The　optimum　volume　ratio　for　the　mixture　of　decalin　and　n-tridecane　was　found　to　be　7:3,　at　which　a　stable　ink　jetting　flow　and　coffee-ring　free　QD　films　could　be　formed.　To　research　the　influence　of　substrate　surface　on　the　formation　of　inkjet-printed　QD　films,　TFB　was　annealed　at　different　temperatures,　and　the　optimum　annealing　temperature　was　found　to　enable　high　quality　inkjet-printed　QD　film.　Inkjet-printed　red　QLED　was　ultimately　manufactured.　A　maximum　18.3%　of　external　quantum　efficiency　(EQE)　was　achieved,　reaching　93%　of　the　spin-coated　QLED,　which　is　the　best　reported　high　efficiency　inkjet-printed　red　QLEDs　to　date.　In　addition,　the　inkjet-printed　QLED　achieved　similar　T75　operational　lifetime　(27　h)　as　compared　to　the　spin-coated　reference　QLED　(28　h)　at　2,000　cd·m−2.　This　work　demonstrated　that　the　novel　orthogonal　halogen-free　alkane　co-solvents　can　improve　the　interfacial　contact　and　facilitate　high-performance　inkjet　printing　QLEDs　with　high　EQE　and　stability.　[Figure　not　available:　see　fulltext.]　©　2021,　Tsinghua　University　Press　and　Springer-Verlag　GmbH　Germany,　part　of　Springer　Nature.