Photocatalysis　is　an　effective　and　environmentally-friendly　technique　for　antibiotics　degradation　in　wastewater.　Herein,　a　novel　rationally　designed　HexaAcetyl-Reductive　Cercosporin/Hydroxyapatite　(HARCP/HAp)　composite　was　simply　fabricated　through　a　convenient　bench-top　fabrication　method　for　the　efficient,　fast　and　complete　removal　of　tetracycline　(TC)　within　10　min　upon　32　W　compact　fluorescent　lamp　(CFL)　irradiation.　The　photoactivity　of　the　fabricated　HARCP/HAp-2　(0.5719　min−1)　to　remove　TC　showed　dramatic　enhancement　compared　with　HARCP　(0.0098　min−1)　or　HAp　(0.0374　min−1).　More　importantly,　a　broad　range　concentration　(30–70　mg　L−1)　of　50　mL　TC　solutions,　even　a　scalable　5　L　solution　at　the　real　situation　of　158　μg　L−1　under　natural　sunlight,　could　be　photoremoved　efficiently　by　this　new　photocatalytic　system.　Meanwhile,　it　exhibited　excellent　stability　and　reusability　for　repeated　usage.　The　photoremoval　process　mechanically　involved　superoxide　radical　anion　(•O2−),　hydroxyl　radical　(•OH)　and　hole　(h+).　Therefore,　we　provided　a　novel　fabrication　of　the　organic-containing　photocatalyst　composite　involving　the　natural　product-derived　HARCP　for　the　efficient　removal　of　TC,　avoiding　the　expensive　and　polluting　heavy　metals,　harsh　conditions　to　fabricate　and　high-power　light　sources.　©　2021　Elsevier　B.V.