The　Late　Devonian　is　considered　as　a　crucial　climatic　transition　from　the　Devonian　greenhouse　to　Carboniferous　icehouse.　Published　Late　Devonian　marine　palaeotemperature　records　are　mainly　based　on　conodont　δ18Oapatite　data　from　the　Rheic　Ocean.　In　order　to　reconstruct　palaeotemperature　variations　in　the　eastern　Palaeotethys,　oxygen　isotopes　were　measured　on　the　latest　Givetian　to　latest　Famennian　conodonts　from　the　Lali　section　(South　China).　Assuming　constant　seawater　δ18O,　the　early　to　middle　Frasnian　is　marked　by　a　warming　trend　(−1.5‰　shift　in　δ18Oapatite),　with　warmest　temperatures　reconstructed　in　FZ　11　(FZ　=　Frasnian　Zonation).　Late　Devonian　cooling　during　the　middle　to　late　Famennian　(velifer　to　ultimus　Zone)　is　documented　by　a　long-term　positive　δ18Oapatite　shift　of　+2‰.　This　increase　corresponds　to　a　similar　δ18Oapatite　increase　in　the　Rheic　Ocean　and　can　be　explained　by　cooling　as　well　as　the　formation　of　ice　masses　as　evidenced　by　the　occurrence　of　glacial　sediments　in　Gondwana　and　Euramerica　during　the　late　Famennian.　The　Late　Devonian　δ18Oapatite　record　largely　matches　2nd-order　T-R　cycles.　The　δ18Oapatite　record　from　the　Lali　section　shows　several　short-term　positive　excursions　coinciding　with　Late　Devonian　bio-events　as　the　Middlesex　(+0.5‰　δ18Oapatite),　Lower　Kellwasser　(+1‰　δ18Oapatite)　and　Upper　annulata　(+0.8‰　δ18Oapatite)　events.　However,　due　to　the　lower　sampling　resolution　of　the　F-F　(Frasnian-Famennian)　boundary　interval,　we　did　not　recognize　a　positive　shift　in　δ18Oapatite　for　the　Upper　Kellwasser　event　as　reported　from　other　sections.　©　2021　Elsevier　B.V.