In　this　work,　the　oxygen　reduction　reaction　(ORR)　process　on　dual-metal-nitrogen-carbon　(DM-N-C)　catalysts　by　including　two　important　factors　(potential　of　zero　charge　and　potential-dependent　kinetics　of　O-O　bond　cleavage)　from　first-principle　calculations　is　systematically　investigated.　Our　results　reveal　that　the　origin　for　the　high　activity　of　dual-metal　sites　can　be　attributed　to　the　fact　that　introducing　a　second　metal　site　can　facilitate　the　O-O　bond　cleavage　in　the　key　OOH*　intermediate　during　ORR　and　meanwhile　mitigate　the　*OH　removal　issue.　Importantly,　we　define　a　descriptor　called　＇antibonding　center＇　that　simplifies　the　evaluation　of　the　kinetics.　Based　on　the　advanced　approach　used　in　this　work,　we　demonstrate　that　several　DM-N-C　electrocatalysts　including　FeFeN6,　FeCoN6,　and　CoZnN6　have　high　ORR　activity　consistent　with　previous　experiments,　and　also　predict　MnCoN6　can　be　more　highly　stable　and　active　for　acidic　ORR.　This　study　demonstrates　the　advantage　of　the　dual　metal　sites　for　the　ORR　in　acidic　electrolyte　and　highlights　the　significance　of　kinetics　in　the　theoretical　study　of　ORR　electrocatalysts.　©　2021　Elsevier　Inc.