Thermoplastic　polyurethane　(TPU)　features　many　important　industrial　applications,　but　intrinsic　flammability　extremely　impedes　its　practical　applications.　Current　fire-retardant　strategies　often　lead　to　improved　flame　retardancy　but　reduced　mechanical　properties　(strength,　ductility,　and　toughness).　Hence,　to　date　it　has　been　unsuccessful　to　design　advanced　TPU　materials　that　are　strong,　stretchable,　tough,　fatigue-and　fire-resistant　to　meet　increasing　performance　portfolio　requirements.　Here,　we　report　a　hybridized　fire　retardant　(Zr-MXene)　by　in　situ　facilely　loading　zirconium　amino-tris-(methylenephosphonate)　(Zr-AMP)　onto　the　titanium　carbide　(MXene)　surface.　Our　results　show　that　with　1　wt%　of　Zr-MXene,　the　resultant　TPU　nanocomposites　demonstrate　a　record　break　strain　(2060%)　and　toughness　(316　MJ/m3)　to　date,　in　addition　to　increased　tensile　strength　by　43.4%　and　improved　fatigue　resistance　relative　to　the　TPU　matrix,　because　of　favorable　interfacial　hydrogen-bonding.　Moreover,　the　resultant　TPU　material　exhibit　significantly　reduced　flammability　as　a　result　of　the　combined　physical　barrier,　catalytical　carbonization　and　diluting　effects　of　Zr-MXene.　This　work　provides　a　promising　strategy　for　the　creation　of　multifunctional　MXene　and　its　polymeric　nanocomposites,　which　hold　great　promise　for　many　industrial　applications.　©　2021　Elsevier　B.V.