Semiconductor　photocatalysts　play　an　indispensable　role　in　the　photocatalytic　process.　Two-dimensional　covalent　organic　frameworks　(2D-COFs),　as　a　kind　of　innovative　photocatalyst,　have　garnered　tremendous　attention.　Herein,　we　report　an　amide-linked　2D-COF　(COF-JLU19)　with　outstanding　photocatalytic　performance　in　water,　designed　through　a　multi-synergistic　approach.　The　synergistic　effects　of　the　high　porosity,　photoactive　framework,　high　wettability,　and　stability　of　COF-JLU19　led　to　an　unprecedented　enhancement　in　the　photocatalytic　activity　and　recyclability　in　water　upon　illumination　by　visible　light.　More　importantly,　amide-linked　2D-COF　based　electrospinning　membranes　were　prepared,　which　also　exhibited　superior　photocatalytic　activity　for　the　degradation　of　Rhodamine　B　in　water　with　sunlight.　This　study　highlights　the　potential　of　the　multi-synergistic　approach　as　a　universal　rule　for　developing　COF-based　photocatalysts　to　address　environmental　and　energy　challenges.　©　2021　Dalian　Institute　of　Chemical　Physics,　the　Chinese　Academy　of　Sciences