Redox-responsive nanoparticles self-assembled from porphyrin-betulinic acid conjugates for chemo- and photodynamic therapy - Details

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The　redox-responsive　nanoparticle　(NanoP-ss-BA)　is　designed　by　linking　the　porphyrin　derivative　(P)　to　the　naturally　occurring　betulinic　acid　(BA)　through　a　disulphide　bond.　A　GSH　triggered　disassembly　of　NanoP-ss-BA　effectively　promotes　a　singlet　oxygen　(1O2)　production,　but　also　releases　lipophilic　anticancer　drug,　BA　in　situ.　Beside　this,　high　phototoxicity　of　NanoP-ss-BA　serves　it　as　a　good　candidate　for　photodynamic　therapy　(PDT).　©　2021　Elsevier　Ltd

Keyword：

Drug delivery Nanoparticles Photodynamic therapy Porphyrins Sulfur compounds

Community：

[ 1 ] [Özdemir, Zulal]Department of Chemistry of Natural Compounds, University of Chemistry and Technology, Prague, Technická 5, Prague 6; 16628, Czech Republic
[ 2 ] [Özdemir, Zulal]Isotope laboratory, Institute of Experimental Botany of the Czech Academy of Sciences, Vídeská 1083, Prague 4; 14220, Czech Republic
[ 3 ] [Yang, Mengyao]Department of Chemistry and Nanoscience, Ewha Womans University, Seoul; 03760, Korea, Republic of
[ 4 ] [Kim, Gyoungmi]Department of Chemistry and Nanoscience, Ewha Womans University, Seoul; 03760, Korea, Republic of
[ 5 ] [Bildziukevich, Uladzimir]Department of Chemistry of Natural Compounds, University of Chemistry and Technology, Prague, Technická 5, Prague 6; 16628, Czech Republic
[ 6 ] [Bildziukevich, Uladzimir]Isotope laboratory, Institute of Experimental Botany of the Czech Academy of Sciences, Vídeská 1083, Prague 4; 14220, Czech Republic
[ 7 ] [Šaman, David]Department of NMR Spectroscopy, Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, Flemingovo námstí 2, Prague 6; 16610, Czech Republic
[ 8 ] [Li, Xingshu]College of Chemistry, Fuzhou University, Fuzhou; 350108, China
[ 9 ] [Yoon, Juyoung]Department of Chemistry and Nanoscience, Ewha Womans University, Seoul; 03760, Korea, Republic of
[ 10 ] [Wimmer, Zdenk]Department of Chemistry of Natural Compounds, University of Chemistry and Technology, Prague, Technická 5, Prague 6; 16628, Czech Republic
[ 11 ] [Wimmer, Zdenk]Isotope laboratory, Institute of Experimental Botany of the Czech Academy of Sciences, Vídeská 1083, Prague 4; 14220, Czech Republic

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Dyes and Pigments

ISSN： 0143-7208

Year： 2021

Volume： 190

5 . 1 2 2

JCR@2021

4 . 1 0 0

JCR@2023

ESI HC Threshold：117

JCR Journal Grade：1

CAS Journal Grade：1

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WoS CC Cited Count：

SCOPUS Cited Count： 6

ESI Highly Cited Papers on the List： 0 Unfold All

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30 Days PV： 0

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