Singlet Oxygen Generation in Dark-Hypoxia by Catalytic Microenvironment-Tailored Nanoreactors for NIR-II Fluorescence-Monitored Chemodynamic Therapy - Details

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Singlet　oxygen　(1O2)　has　a　potent　anticancer　effect,　but　photosensitized　generation　of　1O2　is　inhibited　by　tumor　hypoxia　and　limited　light　penetration　depth.　Despite　the　potential　of　chemodynamic　therapy　(CDT)　to　circumvent　these　issues　by　exploration　of　1O2-producing　catalysts,　engineering　efficient　CDT　agents　is　still　a　formidable　challenge　since　most　catalysts　require　specific　pH　to　function　and　become　inactivated　upon　chelation　by　glutathione　(GSH).　Herein,　we　present　a　catalytic　microenvironment-tailored　nanoreactor　(CMTN),　constructed　by　encapsulating　MoO42−　catalyst　and　alkaline　sodium　carbonate　within　liposomes,　which　offers　a　favorable　pH　condition　for　MoO42−-catalyzed　generation　of　1O2　from　H2O2　and　protects　MoO42−　from　GSH　chelation　owing　to　the　impermeability　of　liposomal　lipid　membrane　to　ions　and　GSH.　H2O2　and　1O2　can　freely　cross　the　liposomal　membrane,　allowing　CMTN　with　a　built-in　NIR-II　ratiometric　fluorescent　1O2　sensor　to　achieve　monitored　tumor　CDT.　©　2021　Wiley-VCH　GmbH

Keyword：

Alkalinity Catalysts Chelation Fluorescence Gas generators Hydrogen peroxide Infrared devices Liposomes Nanoreactors Oxygen Sodium Carbonate Sodium compounds Tumors

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[ 1 ] [Chen, Tao]MOE Key Laboratory for Analytical Science of Food Safety and Biology, College of Chemistry, Fuzhou University, Fuzhou; 350108, China
[ 2 ] [Hou, Peidong]MOE Key Laboratory for Analytical Science of Food Safety and Biology, College of Chemistry, Fuzhou University, Fuzhou; 350108, China
[ 3 ] [Zhang, Yafei]MOE Key Laboratory for Analytical Science of Food Safety and Biology, College of Chemistry, Fuzhou University, Fuzhou; 350108, China
[ 4 ] [Ao, Rujiang]MOE Key Laboratory for Analytical Science of Food Safety and Biology, College of Chemistry, Fuzhou University, Fuzhou; 350108, China
[ 5 ] [Su, Lichao]MOE Key Laboratory for Analytical Science of Food Safety and Biology, College of Chemistry, Fuzhou University, Fuzhou; 350108, China
[ 6 ] [Jiang, Yifan]MOE Key Laboratory for Analytical Science of Food Safety and Biology, College of Chemistry, Fuzhou University, Fuzhou; 350108, China
[ 7 ] [Zhang, Yuanli]MOE Key Laboratory for Analytical Science of Food Safety and Biology, College of Chemistry, Fuzhou University, Fuzhou; 350108, China
[ 8 ] [Cai, Huilan]MOE Key Laboratory for Analytical Science of Food Safety and Biology, College of Chemistry, Fuzhou University, Fuzhou; 350108, China
[ 9 ] [Wang, Jun]MOE Key Laboratory for Analytical Science of Food Safety and Biology, College of Chemistry, Fuzhou University, Fuzhou; 350108, China
[ 10 ] [Chen, Qiushui]MOE Key Laboratory for Analytical Science of Food Safety and Biology, College of Chemistry, Fuzhou University, Fuzhou; 350108, China
[ 11 ] [Song, Jibin]MOE Key Laboratory for Analytical Science of Food Safety and Biology, College of Chemistry, Fuzhou University, Fuzhou; 350108, China
[ 12 ] [Lin, Lisen]MOE Key Laboratory for Analytical Science of Food Safety and Biology, College of Chemistry, Fuzhou University, Fuzhou; 350108, China
[ 13 ] [Yang, Huanghao]MOE Key Laboratory for Analytical Science of Food Safety and Biology, College of Chemistry, Fuzhou University, Fuzhou; 350108, China
[ 14 ] [Chen, Xiaoyuan]Departments of Diagnostic Radiology, Chemical and Biomolecular Engineering, and Biomedical Engineering, Yong Loo Lin School of Medicine and Faculty of Engineering, National University of Singapore, Singapore; 117597, Singapore
[ 15 ] [Chen, Xiaoyuan]Clinical Imaging Research Centre, Centre for Translational Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; 117599, Singapore
[ 16 ] [Chen, Xiaoyuan]Nanomedicine Translational Research Program, NUS Center for Nanomedicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; 117597, Singapore

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Source ：

Angewandte Chemie - International Edition

ISSN： 1433-7851

Year： 2021

Issue： 27

Volume： 60

Page： 15006-15012

1 6 . 8 2 3

JCR@2021

1 6 . 1 0 0

JCR@2023

ESI HC Threshold：117

JCR Journal Grade：1

CAS Journal Grade：2

Cited Count：

WoS CC Cited Count：

SCOPUS Cited Count： 67

ESI Highly Cited Papers on the List： 0 Unfold All

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Chinese Cited Count：

30 Days PV： 0

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