Significant　progress　has　been　made　in　the　application　of　nanoparticle　drug　carriers　in　the　treatment　of　cancer.　However,　the　clearance　of　nanoparticles　by　the　reticuloendothelial　system　limits　their　circulation　time　and　tumor　cell　targeting,　reducing　the　effectiveness　of　drug　delivery.　Herein,　we　construct　a　bionic　core-shell　nanostructure　by　using　a　＇Trojan　horse＇strategy.　The　constructed　biotin　(bio)-modified　red　blood　cell　membrane　(RBCm)-coated　mesoporous　silica　nanoparticle　(MSN)　drug　carrier　(Bio-RBCm@MSN-DOX)　exhibits　excellent　stability,　high　efficiency　of　drug　encapsulation,　and　resistance　to　elimination　by　immune　cells.　Therefore,　Bio-RBCm@MSN-DOX　is　a　sustained　drug　delivery　system　(SDDS)　that　prolongs　circulation　and　enhances　the　effective　drug　release　time.　The　ability　to　target　HeLa　cells　increased　about　4.64　times　and　the　phagocytic　efficiency　of　macrophages　decreased　by　2.55　times.　The　composite　core-shell　structure　developed　here　can　serve　as　a　multifunctional　drug　carrier　system,　which　can　become　a　novel　candidate　for　＇circulating　target-therapy＇carriers.　This　journal　is　©　The　Royal　Society　of　Chemistry　and　the　Centre　National　de　la　Recherche　Scientifique.