Borate　bioactive　glass　(BBG)　stimulates　angiogenesis　and　promotes　cell　growth.　However,　controlling　the　degradation　rate　of　BBG　and　maintaining　the　critical　concentration　of　bioactive　ions　suitable　for　cell　promotion　and　differentiation　remain　great　challenges　in　soft　tissue　repair.　In　this　study,　a　novel　approach　was　proposed　to　produce　nanosized　CO32−-containing　hydroxyapatite　(HCA)-coated　BBG　(nano-HCA@BG).　Unlike　the　previously　reported　hard-to-degrade　hydroxyapatite　(HA)　coating　after　static　soaking　treatment　of　BBG,　the　nano-HCA@BG,　obtained　by　dynamically　immersing　the　BBG　powder　in　a　flowing　buffer,　had　a　porous　structure　and　was　surface-coated　with　a　layer　of　amorphous　HCA,　which　improved　the　biocompatibility　and　retained　the　biodegradability　of　BBG.　The　effects　of　nano-HCA@BG　were　evaluated　and　compared　with　those　of　powdered　BBG　at　the　cellular　and　animal　levels.　The　formation　of　the　HCA-coated　nanoporous　architecture　significantly　improves　biocompatibility,　promotes　cell　growth　and　proliferation,　and　is　beneficial　for　wound　healing　in　rodent　skin　defects.　©　2021