The　treatment　of　diseases　caused　by　drug-resistant　bacterial　infections　urgently　requires　new　types　of　broad-spectrum　antimicrobial　materials.　Herein,　we　introduce　a　supramolecular　self-assembly,　NanoPcN,　which　realizes　the　combination　of　type　I　photodynamic　activity　and　photothermal　effects　by　modifying　zinc(II)　phthalocyanine　with　a　3-(dimethylamino)　phenoxy　group.　Antibacterial　experiments　demonstrate　that　this　＂one-for-two＂　property　endows　NanoPcN　with　excellent　antimicrobial　efficacy,　not　only　against　Gram-positive　and　Gram-negative　bacteria　but　also　against　multidrug-resistant　bacteria.　An　ultralow　concentration　of　NanoPcN　(50　nM)　almost　completely　inhibited　the　growth　of　methicillin-resistant　Staphylococcus　aureus　upon　655　nm　laser　irradiation　(0.5　W/cm2)　for　2　min,　and　the　antibacterial　effect　was　significantly　stronger　than　that　of　the　known　photosensitizers　methylene　blue　and　tetraphenylporphyrin　tetrasulfonic　acid.　Thus,　the　construction　of　＂one-for-two＂　materials　through　a　simple　molecular　structure　modification　paves　a　feasible　way　for　the　development　of　effective　broad-spectrum　antibacterial　agents.