Vascular　thiol　isomerases　(VTIs),　including　PDI,　ERp5,　ERp57,　ERp72,　and　thioredoxin-related　transmembrane　protein　1　(TMX1),　have　important　roles　in　platelet　aggregation　and　thrombosis.　Research　on　VTIs,　their　substrates　in　thrombosis,　their　regulatory　mechanisms,　and　inhibitor　development　is　an　emerging　and　rapidly　evolving　area　in　vascular　biology.　Here,　we　describe　the　structures　and　functions　of　VTIs,　summarize　the　relationship　between　the　vascular　TIs　and　thrombosis,　and　focus　on　the　development　of　VTI　inhibitors　for　antithrombotic　applications.