Magnetic　hyperthermia　is　an　alternative　to　conventional　one　for　cancer　treatment,　which　damages　malignant　cells　by　controlling　treatment　temperature　to　an　acceptable　range.　The　treatment　temperature　distribution　mainly　depends　on　both　magnetic　nanoparticles　(MNPs)　distribution　inside　malignant　tissue　and　the　heat　released　by　the　MNPs　after　subjecting　to　an　alternating　magnetic　field.　The　spatial　distribution　of　MNPs　inside　malignant　tissue　is　strongly　affected　by　many　factors　studied　and　to　be　studied,　which　can　be　injection　rate,　injection　time,　injection　dose,　the　pinhole　size　of　syringe,　and　also　diffusion　time.　Contrary　to　traditional　injection　with　high　rate　(50　ul/min),　this　study　proposes　three　injection　strategies　with　low　rate　(5　ul/min)　for　nanofluid　injection　including　continuous　injection　with　constant　rate,　continuous　injection　with　variable　rate,　and　intermittent　injection　with　constant　rate　under　the　same　nanofluid　dose　(0.3　ml).　All　these　injection　strategies　are　proposed　in　order　to　obtain　better　nanofluid　concentration　distribution　and　further　improve　the　treatment　temperature　distribution　and　the　thermal　damage　situation　for　the　malignant　tissue.　Simulation　results　show　that　all　these　proposed　injection　strategies,　especially　the　continuous　injection　with　variable　rate,　can　effectively　improve　the　physical　field　distribution　for　the　nanofluid　concentration,　the　treatment　temperature,　and　the　thermal　damage　situation　inside　malignant　tissue.　©　2022　Elsevier　Ltd