Bioremediation　of　contaminated　solutions　has　attracted　extensive　attention　in　recent　years　due　to　its　wide　range　of　applicability　to　various　types　of　contaminants　and　environmental　friendliness.　Previous　studies　adequately　confirmed　the　potential　of　Sporosarcina　pasteurii　(i.e.,　S.　pasteurii)-based　bioremediation　for　heavy　metal　contaminated　solutions,　but　they　focused　mainly　on　the　bioremediation　ability　of　single-heavy-metal　contaminated　solutions.　This　study　focuses　on　S.　pasteurii-based　bioremediation　under　more　complex　pollution　conditions.　A　series　of　laboratory　experiments　were　performed　to　explore　the　efficiency　and　mechanism　of　S.　pasteurii-based　bioremediation　to　heavy　metal　contaminated　solutions　under　various　conditions,　including　single-heavy-metal　pollution　condition,　heavy　metal　pollution　under　high　mineral　salinity　context　and　multi-heavy-metal　pollution　scenarios.　The　results　show　that　S.　pasteurii　can　effectively　remove　heavy　metals　such　as　Cd,　Cr(III),　and　Zn　through　biomineralization;　for　the　typical　range　of　mineral　salinity　(including　NaCl　and　KCl)　possibly　encountered　in　practice　in　some　contaminated　solutions,　such　as　leachate　of　landfills,　the　detrimental　influence　of　high　mineral　salinity　on　efficiency　of　S.　pasteurii-based　bioremediation　can　be　neglected;　more　importantly,　S.　pasteurii-based　bioremediation　can　be　considered　as　a　potential　option　for　remedying　multi-heavy-metal　contaminated　solutions,　though　the　addition　of　some　heavy　metals　tends　to　produce　a　substantially　detrimental　influence　on　the　bioremediation　ability　of　S.　pasteurii　to　other　heavy　metals.　©　2022　by　the　authors.　Licensee　MDPI,　Basel,　Switzerland.