Polysaccharide　hydrogels　are　widely　applied　as　wound　dressings　for　skin　wound　repair　due　to　their　good　biocompatibility　and　ability　to　regulate　microenvironments.　However,　hydrogel　application　can　result　in　skin　wetting　that　can　easily　cause　wound　infections.　Herein,　a　polysaccharide-based　antibacterial　hydrogel　that　can　promote　skin　wound　repair　is　prepared　by　a　one-pot　method.　In　this　study,　tannic　acid　(TA)　is　oxidized　and　cross-linked　with　carboxymethyl　chitosan　(CMCS)　through　a　Schiff　base　reaction　to　form　the　macromolecule　CMCS-TA.　Carboxymethyl　cellulose　(CMC)　cross-links　more　easily　with　CMCS-TA　than　CMCS　when　utilizing　the　cross-linking　agent　carbondiimide　hydrochloride　(EDC).　EDC　has　no　cytotoxicity　after　hydrolysis　and　the　hydrogel　prepared　by　EDC　cross-linking　has　a　low　swelling　rate.　Due　to　the　in　situ　reduction　of　Ag　particles,　the　CMC/CMCS-TA/Ag　hydrogel　exhibits　good　antibacterial　properties　against　E.　coli　and　S.　aureus.　Cytocompatibility　tests　and　histological　analysis　indicate　that　the　antibacterial　hydrogel　has　good　biocompatibility　and　can　promote　wound　repair　in　a　rat　infection　model.　Therefore,　the　polysaccharide-based　hydrogel　can　be　a　promising　wound　dressing　for　skin　wound　repair.　©　2022　Wiley-VCH　GmbH